LIM KAH MIN, 061311133255 (2017) THE EFFECTIVENESS OF ACTIVE CURCUMIN AS AN ANTIOXIDANT ON THE MICE (Mus musculus) INDUCED BY METHYL MERCURY ON THE HISTOPATHOLOGY OF RENAL TUBULES. Skripsi thesis, Universitas Airlangga.

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Abstract

This research was carrying out to study the effectiveness of active curcumin as an antioxidant on the mice (mus musculus) induced by Methyl Mercury on the histopathology of renal tubules. Twenty male mice were divided into four groups, each treatment group included five mice and administered through orally for 30 days. The treatments were group C- (0.3 ml distilled water + 0.5 ml of CMCNa 0.5% solution), group C+ (0.0028 mg / KgBW Methyl Mercury + 0.5 ml of CMCNa 0.5% solution), group T1 and T2 (150, 300 mg / KgBW curcumin + 0.0028 mg / KgBW Methyl Mercury). After all the treatments for 30 days consecutively, histopathological evaluation was done by calculating the degree changes of the kidney preparation with Arsad scoring method. The data was analyzed by using Kruskal-Wallis test and Mann-Whitney test. The research result did not show significant difference (p<0.05) among all the treatment groups. Based on research that has been done, it can be concluded that the curcumin as an antioxidant cannot reduce renal tubular damage which exposure to Methyl Mercury from histopathological changes.

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