TITIS JESICA AVIV, 061311133232 (2017) POTENSI PERLINDUNGAN PASTA TOMAT (Lycopersicon esculantum) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL MENCIT (Mus musculus) YANG DIPAPAR BORAKS. Skripsi thesis, Universitas Airlangga.

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Abstract

This research was aimed to evaluate the potential protection of tomato paste (Lycopersicon esculatum) against kidney histopathologic picture of mice (Mus musculus) exposed to borax. Twenty-four male mice (Mus musculus) 60-90 days old with average weight of 20 g is used. These animals were divided into six groups (P0, P1, P2, P3, P4, and P5). P0 treated with sterile aquadest of 0.1 ml / 20g Bw / day, P1 is treated with borax 7.5 mg / 20g Bw / day, P2 is treated with tomato paste 0,3 g / 20g Bw / day, P3 is treated with tomato paste 0 , 15 g / 20g Bw / day and borax 7.5 mg / 20g Bw / day, P4 is treated with tomato paste 0,3 g / 20g Bw / day and borax 7.5 mg / 20g Bw / day, and P5 treated with tomato paste 0.45 g / 20g Bw / day and borax 7.5 mg / 20g Bw / day. This research has been conducted for 14 days. Data were compared using non-parametric test of Kruskal-Wallis and showed that among the treatment group contained significant effect (p <0.05), then continued with Man- Whitney test using SPSS 20.0 for windows. The results showed that the tomato paste 0.45 g / BB 20g daily can reduce the degree of kidney damage in mice exposed to borax significantly (p <0.01).

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