RAIS RAZAK, 051314153009 (2016) SINTESIS DAN HUBUNGAN KUANTITATIF STRUKTUR-AKTIVITAS ANALGESIK TERHADAP MENCIT (Mus musculus) DARI BEBERAPA TURUNAN N-ALIL-N’-BENZOILTIOUREA. Thesis thesis, Universitas Airlangga.

Preview	Text (ABSTRAK) 1. ABSTRAK TF 03-17 Raz s.pdf Download (72kB) | Preview
	Text (FULLTEXT) 2. FULLTEXT TF 03-17 Raz s.pdf Restricted to Registered users only Download (1MB) | Request a copy

Abstract

Synthesis and Quantitaive Structure-Activity Relationship N-allyl-N’- benzoylthiourea Derivatives as Analgesic on Mice (Mus musculus). Synthesis the new compounds of N-allyl-N’-benzoylthiorea derivatives (i.e N-allyl-N’- benzoylthiorea; N-allyl-N’-(-4-methylbenzoyl)thiorea; N-allyl-N’-(4-methoxy benzoyl)thiorea; and N-allyl-N’-(4-tertiarybutylbenzoylthiorea) has been done. The Modified Schotten Baumann was used for the reaction between Nallylthiourea with benzoyl chloride derivatives (i.e benzoyl chloride; 4- methylbenzoyl chloride; 4-methoxybenzoyl chloride; and 4-tertiarybutylbenzoyl chloride). The compound yield was 47% (N-allyl-N’-benzoylthiorea), 37,7% (Nallyl- N’-(-4-methylbenzoyl)thiorea), 35,2% (N-allyl-N’-(4-methoxy benzoyl)thiorea), and 25,3% (N-allyl-N’-(4-tertiarybutylbenzoylthiorea), had a white crystalline, one spot in Thin Layer Chomatography with three different eluents, and different melting point from N-allylthiourea for each compounds. The structure identification for the new compounds of N-allyl-N’- benzoylthiorea derivatives was analysed by Ultra-Violet, Infrared, 1H-NMR, and 13C-NMR. The results showed that new compounds was as expected, ie N-allyl- N’-benzoylthiorea derivatives. The analgesic activity test was done for four derivatives of N-allyl-N’- benzoylthiorea by Writhing Test Method on mice (Mus musculus) and compared with natrium diclofenac as the standart compound. The test showed that three Nallyl- N’-benzoylthiorea derivatives (N-allyl-N’-(-4-methylbenzoyl)thiorea; Nallyl- N’-(4-methoxy benzoyl)thiorea; and N-allyl-N’-(4- tertiarybutylbenzoylthiorea) has higher analgesic activity than natrium diclofenac with N-allyl-N’-(-4-methylbenzoyl)thiorea has the highest analgesic activity. Whereas, the lead compound has same activity with natrium diclofenac. QSAR studies showed the best correlation belongs to parabolic relationship between lipophilic parameter (ClogP) and analgesic activity on mice (Mus musculus) with equation Log 1/ED50 = 2,926 ClogP – 0,524 ClogP2 -5,179.

Actions (login required)

View Item