Suciati and Irsyad Abdillah and Muhammad Ihsan Uddin and Achmad Fauzi and Myrna Adianti and Achmad Fuad Hafid (2017) Antiviral Activity of Marine Sponges Homaxinella tanitai and Microxina subtilis against Hepatitis C Virus. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 8 (1). pp. 1642-1647. ISSN 0975 - 8585

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Abstract

The aim of the study was to screen antiviral activity of marine spooges extracts and fractions against hepatitis C virus, as well as to investigate the mode of action of the extract. The results showed that extracts of marine sponges Homaxinella tanitai dan Microxino subtilis inhibited the growth of HCV at lc5oof 27.1 and 4o-5 gg/ml respectively. Three fractions from H. tanitai and two fractions from M- subtilis gave more than 50% inhibiton againts HCV at concentration 100 [g/ml. The time of additkm experamcnt revealed that H- tonitoi and M. subtilis extracts both act at enty and post entry steps. These results suggest that H tanitai and M. subtilis extracts could serve as potential candidates for antiviral agents gainst hepatitis c virus.

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