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	<title>Toll-like receptor–4 gene polymorphisms in Javanese aggressive and chronic periodontitis patients | Prahasanti | Dental Journal (Majalah Kedokteran Gigi)</title>
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			<meta name="keywords" content="gene polymorphisms; TLR4; aggressive periodontitis; chronic periodontitis" />
	
	
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	<meta name="DC.Contributor.Sponsor" xml:lang="en" content=""/>
	<meta name="DC.Creator.PersonalName" content="Chiquita Prahasanti"/>
	<meta name="DC.Date.created" scheme="ISO8601" content="2015-12-31"/>
	<meta name="DC.Date.dateSubmitted" scheme="ISO8601" content="2016-07-25"/>
	<meta name="DC.Date.issued" scheme="ISO8601" content="2015-12-31"/>
	<meta name="DC.Date.modified" scheme="ISO8601" content="2016-08-09"/>
	<meta name="DC.Description" xml:lang="en" content="  Background:    Tool-like receptor-4    (   TLR4) gene polymorphisms affect the ability of the host in response to pathogenic bacteria,    and can also be associated with the severity of periodontitis. TLR4 gene polymorphisms (Asp299Gly and Thr399Ile) are ones of gene    mutations that occur in patients with aggressive periodontitis.    Purpose:    To investigate the involvement of TLR4 gene polymorphism    as a risk factor of aggressive and chronic periodontitis of Javanese population in Surabaya.    Method:    This research can be considered    as an analytic observational study, with a case-control study design in patients with aggressive periodontitis and chronic periodontitis.    DNA samples were derived from peripheral blood. TLR4 gene polymorphisms (Asp299Gly and Thr399Ile) were then observed by    PCR-RFLP.    Result:    There was no TLR4 gene polymorphism (Asp299Gly) in the whole samples. And, based on the results of simple    logistic regression analysis on TLR4 gene polymorphisms (Thr399Ile), mutants heterozygote and homozygote obtained had OR value    about 0.25.    Conclusion:    In Surabaya, there was no heterozygote and homozygote mutant in TLR4 gene polymorphisms, (Asp299Gly)    and (Thr399Ile), that can be considered as risk factors of chronic periodontitis.                       "/>
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	<meta name="DC.Source" content="Dental Journal (Majalah Kedokteran Gigi)"/>
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	<meta name="DC.Source.Volume" content="48"/>						<meta name="DC.Subject" xml:lang="en" content="gene polymorphisms"/>
								<meta name="DC.Subject" xml:lang="en" content="TLR4"/>
								<meta name="DC.Subject" xml:lang="en" content="aggressive periodontitis"/>
								<meta name="DC.Subject" xml:lang="en" content="chronic periodontitis"/>
				<meta name="DC.Title" content="Toll-like receptor–4 gene polymorphisms in Javanese aggressive and chronic periodontitis patients"/>
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        <meta name="citation_author" content="Chiquita Prahasanti"/>
        <meta name="citation_author_institution" content="Department of Periodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya"/>
<meta name="citation_title" content="Toll-like receptor–4 gene polymorphisms in Javanese aggressive and chronic periodontitis patients"/>

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		<em>Chiquita Prahasanti</em>
								<br />Department of Periodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya		<br />Indonesia	</p>

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