Eza Cahya Prawita, 061311133129 (2017) PENGARUH PEMBERIAN EKSTRAK ETANOL BAWANG BOMBAY (Allium ceppa L.) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Airlangga.

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Abstract

This study was obtained to determine antidiabetic effect of repeated oral administration of onion extract (Allium ceppa L.) in alloxan induced diabetic rats (Rattus norvegicus). Alloxan were intraperitoneally injected 120 mg/KgBW (single dose). A total of twenty male wistar rats of three months old were used this study. The rats were divided into five groups. 1) negative control group (K-) was treated by CMC Na 0.5 %, 2) positive control group (K+) had been inducted by alloxan and treated by CMC Na 0.5 %, 3) group 1 (P1) had been inducted by alloxan and treated by extract of Allium ceppa L 200 mg/KgBW, 3) group 2 (P2) had been inducted by alloxan and treated by extract of Allium ceppa L 400 mg/KgBW 4) group 3 (P3) had been inducted by alloxan and treated by extract of Allium ceppa L 800 mg/KgBW. Blood specimen were collected from coccygealis vein, then analyzed using easytouch glucometer. The result of this study showed that Allium ceppa L extract had high antidiabetic potential which decreased the blood glucose in 14 days post treatment. Allium ceppa L consisted of allyl prophyl disulphide and queercetin that could reduced the blood glucose level. After 14 days post treatment, the averaged result of blood glucose levels in dose 200 mg/KgBW (P1) and dose 800 mg/KgBW (P3) didn’t approached the negative control’s (K-) therefore the effective dose of Allium ceppa L that could reduced the blood glucose level was 400 mg/KgBB.

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