GIBRAN DEWANDA, 061311133103 (2017) Potensi Pemberian Kurkumin Pada Mencit (Mus musculus) yang Dipapar Metilmerkuri Terhadap Jumlah Sel Pyramid. Skripsi thesis, Universitas Airlangga.

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Abstract

Curcumin is an antioxidant compound that can counteract free radicalsThe experiment was conducted to know the histopathological view of pyramid cell on cerebrum of mice (Mus musculus) due to methylmercury exposure which administrated with curcumin agent. Twenty mice’s divided into four group with 30 day treatment. The control grup (k-) was given 0,5 ml aquades, k+ (methylmercury 0,0056 mg/kg), P1 (methylmercury 0,0056mg/kg + curcumin 150 mg/kg) and P2(methylmercury 0,0056 mg/kg + curcumin 300 mg/kg). Day 30 all mice were sacrified for histopathological examination. The result of the experiment get through examination of total pyramid cell necrosis that observed by light microscope with 400x magnification. The data was analyzed by ANOVA and Honestly Significant Difference test (DUNCAN). Result showed that the number of pyramid cell necrosis decreased in compliance with the dose of Curcumin administration. The conclusion of this research Curcumin can decrease the number of necrosis cell

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