NINDA RUBI PRAMESTYA, 061311133208 (2017) PENGARUH PEMBERIAN EKSTRAK BONGGOL PISANG AMBON (Musa paradisiaca var. sapientum) TERHADAP EKSPRESI TUMOR NECROSIS FACTOR ALPHA(TNF-α) PADA LAMBUNG TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI INDOMETASIN. Skripsi thesis, Universitas Airlangga.

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Abstract

The purpose of this research was to prove the role of ambon banana stem (Musa paradisiaca var. sapientum) against inflammation as measured by decreased expression of Tumor Necrosis Factor Alpha (TNF-α) in gastric of rat (Rattus norvegicus). Twenty rats (Rattus norvegicus) with 8-12 week ages and 150-200 g avarage of body weight were divided into five groups (K-, K+, P1, P2 and P3). K- and K+ as control, P1 was treated with ambon banana stem extract dose 200mg/kg BW, P2 was treated with ambon banana stem extract dose 400mg/kg BW, P3 was treated with ambon banana stem extract dose 800/kg BW. This research has been conducted for 13 days. The data of TNF-α expression were analyzed with Kruskal-Wallis and continued with Man-Whitney. Result showed there were significant (p<0.05) different between treatment groups. This research conclued that ambon banana stem extract with dose 800mg/kg BW can prevent gastritis on gastric of rats.

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