TEGUH BAGUS PRIBADI, 061211133108 (2016) GAMBARAN HISTOPATOLOGI GINJAL MENCIT (Mus musculus) MODEL HIPERGLIKEMIA YANG DITERAPI EKSTRAK GULMA RUMPUT BERMUDA (Cynodon dactylon) FRAKSI NON-POLISAKARIDA. Skripsi thesis, Universitas Airlangga.

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Abstract

This study was undertaken to investigate the hypoglicemic effect of repeated oral administration of the non-polisacharide fraction of aqueous extract of Cynodon dactylon (NPF-CD) in overload glucose induced hyperglicemic mice, overload glucose multiple low doses were oral administered 2 kg/BW for 15 days. A total of thirty male BALB-C mice of two months old were used in this study. The mice were devided into five groups:(1) normal group (K0), mice without giving any, (2) Group negative control (K-) mice hyperglycemia without therapy, (3) the positive control group (K+) mice hyperglycemic and treated metformin as standard drugs, (4) NPF-CD 250 mg/kgBW (P2) , (5) NPF-CD 500 mg/kgBW (P3), (6) NPF-CD 750 mg/kgBW (P4), (7) NPF-CD 1000mg/kgBW, The treatment is carried out for 10 days.At the end of the experiment, all the mice eutanized and kidneys on the dexter were collected by abdominal section, and observed whether there is improvement that occurs in renal tubular cells including parameters observed lesions is the presence of degeneration, necrosis and protein cast. This research using Kruskal-Wallis analysis and if significantly different results followed by a multiple comparison test (Z test). The result of this study showed that non-polysacharide fraction of aqueous extract of Cynodon dactylon has high antidiabetic potential at hypoglicemic and keep the quality of renal tubular cells. Comparatively, the NPF-CD 250 mg/kgBW was found to be more effective than the metformin as a standart drug.

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