Ramli, Rosdayati Alino and Pudjiastuti, Pratiwi and Tjahjandarie, Tjitjik Srie and Lie, Wilford and Rattanajak, Roonglawan and Kamchonwongapaisan, Sumalee and Pyne, Stephen G. (2015) Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their antimalarial, acetylcholinesterase inhibitory and cytotoxic activities. Phytochemistry Letters, 11. pp. 157-162. ISSN 1874-3900

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Abstract

Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S*),12(R*) dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 ± 3.7, 16.8 ± 5.4, 16.0 ± 4.2 μg/mL, respectively) and K1 (IC50 values of 16.8 ± 3.1, 14.1 ± 3.7, 11.9 ± 3.3 μg/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities.

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