Tanjung, Mulyadi and Saputri, Ratih Dewi and Fitriati, Faiz Fakhriah and Tjahjandarie, Tjitjik Srie (2016) Antimalarial and Antioxidant Activities of Isoprenylated Coumarins from the Stem Bark of Mesua borneensis L. Journal of Biologically Active Products from Nature, 6 (2). pp. 95-100. ISSN 2231-1874

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Abstract

The aim of this study was to assess the antimalarial and antioxidant effects of the n-hexane and ethyl acetate extracts together with three isolated isoprenylated coumarins, mammea A/BA(1),mammea A/ AA cyclo D (2) and mesuol (3) from the stem bark of M. borneensis L. The n-hexane and ethyl acetate extracts, as well as compounds 1-3 were evaluated for their antimalarial activity against Plasmodium falciparum strain 3D7 (chloroquine-sensitive) and their antioxidant activity against DPPH radical scavenging. Compound 2 exhibited slightly more active than chloroquine. Compounds 1 and 3 showed very high activity against DPPH radical.

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