A NOVEL SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CHLORAMPHENICOL BASED ON DIAZOTIZATION REACTION AT ROOM TEMPERATURE

Wafi, Abdul and Supriyanto, Ganden and Tjahjandarie, Tjitjik Srie (2015) A NOVEL SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CHLORAMPHENICOL BASED ON DIAZOTIZATION REACTION AT ROOM TEMPERATURE. Indonesian Journal of Chemistry, 16 (1). pp. 32-35. ISSN 1411-9420

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Official URL: https://journal.ugm.ac.id/ijc/index

Abstract

An analytical method for determination of chloramphenicol (CAP) based on the diazotization reaction at room temperature has been developed. The CAP was reduced using zinc powder (Zn) and diazotization reaction was carried out at room temperature in the presence of NaNO2, bismuth nitrate pentahydrate (Bi(NO3)3.5H2O) as catalyst. 2-napthol was used as coupling agent to form a red-violet solution and the absorbance was measured by UV-Vis spectrophotometer at 554 nm. The optimization of analytical parameters including reducing agent, catalyst, coupling agent and time response were 0.15 g, 0.15 g, 230.67 µg/mL and 8-9 min respectively.

Item Type: Article
Uncontrolled Keywords: azo dye; chloramphenicol; diazotization reaction; spectrophotometry
Subjects: Q Science > QD Chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Creators:
CreatorsNIM
Wafi, AbdulUNSPECIFIED
Supriyanto, GandenUNSPECIFIED
Tjahjandarie, Tjitjik SrieUNSPECIFIED
Depositing User: Mr Akhmad Nurfizal Reza
Date Deposited: 12 Oct 2017 23:46
Last Modified: 12 Oct 2017 23:46
URI: http://repository.unair.ac.id/id/eprint/63047
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