RINA SUTJIATI, NIM011317017301 (2016) MEKANISME HAMBATAN RELAPS PERGERAKAN GIGI ORTODONTI PADA PEMBERIAN NATRIUM FLUORIDA (NaF) (Studi Eksperimental Pada Tikus Wistar). Disertasi thesis, Universitas Airlangga.
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Abstract
Background: Alveolar bone remodeling is very helpful in orthodontic treatment, particularly to prevent relapse after orthodontic treatment. Currently, the prevalence of post-treatment relapse in orthodontics in the community is high enough; therefore, the prevention of relapses makes orthodontic treatment be achieved well. Objectives: to experimentally test the mechanism of orthodontic tooth movement due to natrium fluoride (Naf) administration. Material and methods: the research method used was experimental laboratory research involving 30 rats, which were divided into 3 goups. Group A: the rats were not given OTM and without 11.75 ppm by topical application. Group B: the rats were given OTM and without 11.5 ppm by topical application. Group C: the rats were given OTM and 11.75 ppm by topical application. OTM was conducted by applying ligature wires of 0.02 mm in diameter on the molar-1(M-1) of left emanent maxilla and left insisivus of maxilla. Immunohistochemical examination was conducted to calculate the number of osteoblast to determined TGF β1, Runx2, Sox2, ALP and Collagen type 1 and haematoxyllin to determine Woven Bone on day 7 and day 14. Results: It was shown that administration of Natrium Fluoride topical application proved effective to increase the esxpression of TGF β1, Runx2, Sox2, ALP and Collagen type1 and to increase Woven Bone in tension area greter compaired with administration without Natrium Fluoride topical application (p<0,05), except for the expression of ALP on day 7 and day 14 which was significant. Conclusions: NaF administration significantly increased TGF β1, Runx2, Sox2, ALP and Collagen type1 and Woven Bone. The expression of the variables enhanced on day 7 compared to that on day 14, except for ALP. Thus, it can be said that the acceleration of woven bone occurs on day 7.
| Item Type: | Thesis (Disertasi) | |||||||||
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| Additional Information: | KKA KK Dis.K.244/17 Sut m | |||||||||
| Uncontrolled Keywords: | TGF β1, Runx2, Sox2, ALP, Kolagen type1, Woven Bone, Natrium Fluoride. | |||||||||
| Subjects: | R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research | |||||||||
| Divisions: | 01. Fakultas Kedokteran | |||||||||
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| Depositing User: | Mr Binkol1 1 | |||||||||
| Date Deposited: | 27 Dec 2017 18:14 | |||||||||
| Last Modified: | 18 Jan 2018 21:07 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/63519 | |||||||||
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