RAHMAWATI RAISING, 051415153011 (2017) PENGARUH SUPLEMENTASI PROBIOTIK DAN VITAMIN B1, B6, B12 TERHADAP PERUBAHAN KADAR IFN-γ DAN IL-12 PADA PASIEN TUBERKULOSIS DENGAN OBAT ANTI TUBERKULOSIS KATEGORI 1. Thesis thesis, Universitas Airlangga.
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RAHMAWATI RAISING 051415153011 - PENGARUH SUPLEMENTASI PROBIOTIK DAN VITAMIN B1 B6 B12 IFN DAN IL12 (2).pdf Restricted to Registered users only until 16 October 2020. Download (2MB) |
Abstract
Tuberculosis is an acute infectious disease that primarily affects the lungs. Probiotic supplementation proved to increase the number and activity of NK cell in peripheral blood by immunomodulation by IL-12, thus can increase IFN- γ production by Th1 response. Vitamin B1 acts on macrophages and affects neutrophil motility. Vitamin B6 is associated with the release of cytokines and the responsiveness of NK cells, vitamin B12 affects to lymphocytes, T cell proliferation, CD4+ ratios, and NK cell activity. Objectives: This study aimed to analyze the effects of probiotics and vitamin B1, B6, B12 suplementation on IFN-γ and IL-12 levels in patients with TB infection during intensive phase therapy. Methods: This study was conducted on December 2016 to February 2017 at Universitas Airlangga Hospital and Community Health Centers in Surabaya. Patients were divided into two groups standard regimen group and treatment group with once daily supplementation of probiotics and vitamin B1, B6, B12. Primary outcomes were measured plasma IFN-γ and IL-12 levels before initiation of study, after one month and two months after treatment. Results: 22 patients were divided into two groups. Plasma IFN-γ levels in the control (p=0.445) and treatment group (p=0.241) increased in first month then decreased after second months. Plasma IL-12 levels in control (p=0.091) and treatment group (p=0.061) increased in first month then decreased after second months. Conclusion: Therapy of probiotics and vitamin B1, B6, B12 suplementation tend to increase plasma IFN-γ and IL-12 levels in the first month and decrease in the second month
| Item Type: | Thesis (Thesis) | ||||||
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| Additional Information: | KKB KK-2 TFK 29/17 Rai p | ||||||
| Uncontrolled Keywords: | IL-12, IFN-γ, Probiotic, Tuberculosis infection, Vitamin B1, B6, B12 | ||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | ||||||
| Divisions: | 05. Fakultas Farmasi > Farmasi Klinis | ||||||
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| Depositing User: | Unnamed user with email indah.fatma@staf.unair.ac.id | ||||||
| Date Deposited: | 16 Oct 2017 00:27 | ||||||
| Last Modified: | 16 Oct 2017 00:27 | ||||||
| URI: | http://repository.unair.ac.id/id/eprint/63943 | ||||||
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