BAYU INDRA SUKMANA, 021314153010 (2017) POTENSI FRAKSI KULIT BATANG Mangifera casturi 12,7% TERHADAP EKSPRESI IL-1β DAN BMP-2 SELAMA REMODELING TULANG SETELAH PENCABUTAN GIGI. Thesis thesis, Universitas Airlangga.

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Abstract

The main problem of Indonesian oral health is the high number of tooth decay. Tooth extraction is an action which is often experienced by patient who have tooth decay and the wound caused alveolar bone resorption. Bark of Mangifera casturi has been researched containing secondary metabolite which has ability to increase osteoblast’s activity and suppress osteoclast’s activity. Objective: The purpose of this study analyzed the IL-1β and BMP-2 activity during the bone remodeling after Mangifera casturi’s bark fraction treatment. Methods: This study used 40 male Wistar rats which are divided in 4 group. The Mangifera casturi bark extraction was done by 96% ethanol maceration and nhexane fractionation. The extraction was done on mandible incisive tooth. The research material in each treatment group a Mangifera casturi (Kosterm.) gel extract dose of 6,35%, 12,7%, and 25,4%. Wistar’s mandible were decapitated at interval 7 and 14 days after extraction. The antibody staining on preparations for the examination of IL-1β and BMP-2 expressions was done by immunohistochemistry.

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