Amanda Muhamad Bauzir, NIM011180501 (2017) EFEKTIVITAS PENAMBAHAN KORTIKOSTEROID INTRANASAL TERHADAP WAKTU TRANSPOR MUKOSILIAR DAN SKOR GEJALA HIDUNG TOTAL PENDERITA RINITIS ALERGI YANG MENDAPAT TERAPI LORATADIN. Thesis thesis, Universitas Airlangga.

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Abstract

Objective : Our objective wasto prove the effectivity of INC addition on loratadin treatment in lowering TNS scores and mucocilliary transport time compared to loratadine single treatment on allergic rhinitis (AR) patients. Method : Fourty patients with moderate-to-severe intermittent AR and mild persistent AR participated at this randomized pre-post test with control group design research. We performed consecutive collection of AR patients at Allergy–Immunology Division of ORLHNS Outpatient Department of Dr. Soetomo Hospital, Surabaya.Samples were performed pre treatment TNS score examination and mucocilliary transport time and then divided into 2 groups, group A with loratadine treatment and group B with INC addition to loratadine standard treatment. All samples went through post treatment TNS score examination and mucocilliary transport time measurement after 14 days. Result :Comparison of TNS scores between group A and B was analyzed statistically and the result were significantly different (p=0.001). After treatment, the lowering of TNS score between group A and B was significantly different (p=0.001). Mucociliary transport time analysis in both groups showed significantly different (p=0,001 and 0,000) and the decrease of mucocilliary transport time in both groups also significantly different (p=0,000). Conclusion : Intranasal corticosteroid addition to loratadine is more effective treatment compared to loratadine single treatment in lowering total nasal symptom score and mucocilliary transport time in allergic rhinitis patients.

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