EVA YUNIAR AGUSTIN, 051211131040 (2017) UJI AKTIVITAS ANTIDIABETES EKSTRAK KERING HERBA SAMBILOTO (Andrographis paniculata Nees.) PADA MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Airlangga.

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Abstract

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. This research aimed to evaluate antidiabetic activity of dry extract Andrographis paniculata Nees. herbs in alloxan induced mice. Dry extract is an extract of the added powder fillers, such as lactose, Avicel, maltodextrin, starch or other inert filler materials with a certain ratio, then dried in a drying cabinet (oven). All mice were is induced with 186,9 mg/kg body weight, alloxan diluted in buffer citrate to induce hyperglycemia. Dry extract Andrographis paniculata Nees. herbs with dose 28,57 mg/20g body weight mice, 57,14 mg/20g body weight mice and 114,28 mg/20g body weight mice, was administrated orally every 24 hour on groups III, IV and V. Standard drug Glibenclamide 3 mg/kg body weight (0,06 mg/20 g body weight mice) is used as positive control and CMC-Na 0,5% as negative control. Blood glucose levels were determined at 0, 2, 4, 6 and 24 hour. After treatment, groups III, IV and V showed that the extract significantly reduce blood diabetic level in hyperclycemia mice. Dry extract of Andrographis paniculata Nees. herbs with of a dose 114,28 mg/20 g body weight mice showed the highest reduction in blood diabetic 168,50 ± 54,04 mg/dL. Dose 28,57 mg/20 g body weight mice showed the lowest reduction on blood diabetic 119,67 ± 30,12 mg/dL. The third dose has no significant difference in lowering blood sugar levels, the most effective dose was at 114,28 mg/20 g body weight mice.

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