EKA RUSMALINA HARDIYANTI, 051211131032 (2017) AKTIVITAS ANTIMALARIA GRANUL FRAKSI ETIL ASETAT-96 DAN FRAKSI ETIL ASETAT-70 HERBA SAMBILOTO (Andrographis paniculata NEES) IN VIVO PADA MENCIT TERINFEKSI Plasmodium berghei. Skripsi thesis, Universitas Airlangga.

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Abstract

This study aim was to determine the antimalarial activity of granule from ethanol 96% and ethanol 70% extract of Sambiloto which fractionated with ethyl acetate (namely ethyl acetate-96 and ethyl acetate-70 fractions). Antimalarial activity test was conducted based Peter Test (The 4- day suppressive test of blood schizontocidal action) used P. berghei infected mice. Mice were divided into 10 groups, group 1-8 treated with granule at a dose of 6.25, 12.5, 25, and 50 mg/kg BW, CMC-Na 0.5% as negative control and choloroquine 10 mg /kg BW as positive control. Probit analysis result showed that ethyl acetate-96 and ethyl acetate-70 fraction granules has ED50 value of 6.81 mg / kg BW, and 10.16 mg / kg BW respectively. Ethyl acetate-96 fraction granules showed higher activity than ethyl acetate-70 fraction granules. Further more, both granule proven can increase survival time compared to negative control.

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