SARAH AMRILLAH, 051311133171 (2017) UJI AKTIVITAS ANTASIDA DAN ANTIFLATULEN SIRUP EKSTRAK ETANOL 70% BIJI SELASIH (Ocimum sanctum) SECARA IN VITRO. Skripsi thesis, Universitas Airlangga.

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Abstract

This study aims to prove the acid neutralization and antiflatulent activities of 70% ethanolic extract of Holy Basil seed (Ocimum sanctum) which formulated in syrup dosage form. Antacid activity preparations were used in vitro artificial gastric model based on Wu et al. method, and antiflatulent (foam removal test) activity used 500 ml beaker glass based on Rezak modification method. The results of antacid activity group test of 70% ethanolic extract syrup of Holy Basil seed at 0.1%, 0.15%, and 0.2% were found to possess acid neutralization with average duration of 97.57 ± 8.23 minutes, 138.72 ± 7.51 minutes, and 65.63 ± 15.95 minutes, respectively. The results of antiflatulent activity group test showed defoaming activity with the rest of the foam level of 1.4 ± 0.1 cm, 1.0 ± 0.1 cm, and 0.5 ± 0.1 cm, respectively. All of the results were statistically analyzed by using one way anova and Post Hoc Test with Least Significance Difference (LSD) method. The p values of all concentrations of antacid and antiflatulent activities were below 0.05, which shows a significant difference compared to the negative control (syrup without extract). It is concluded that 70% ethanolic extract syrup of Holy Basil seed had antacid and antiflatulent activities.

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