AMIROTUL FAIQOH AZMI, 051311133080 (2017) STUDI AKTIVITAS ANTI-HCV TERHADAP VIRUS JFH1a PADA TANAMAN DARI SUKU LAURACEAE YANG TUMBUH DI KEBUN RAYA BALIKPAPAN, KALIMANTAN TIMUR. Skripsi thesis, Universitas Airlangga.

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Abstract

Eusideroxylon zwageri, Alseodaphne elmeri, and Neolitsea cassiaefolia are plants from Lauraceae family. Previous research reported that several compounds showed hepatitis C activity such as terpenoids, flavonoids, and alkaloids. These plants then gradually extracted using hexane, dichloromethane, and methanol solvent and screened for antihepatitis C virus activity using JFH1a infected in Huh7it cell culture system and cytotoxicity assay using Huh7it cell. The results showed that dichloromethane extract of N. cassiaefolia leaves has the highest inhibition percentage 92,90% ± 3,86%. Cytotoxic assay result showed the percentage of cell viability from the dicloromethane extract of Neolitsea cassiaefolia leaves 64,655 ± 7,315% compare to control. Further separation of dichloromethane extract of Neolitsea cassiaefolia leaves using Thin Layer Chromatography showed purple spot that indicate terpenoid substances. In conclusion dichloromethane extract of Neolitsea cassiaefolia leaves contained terpenoid and has the highest activity against HCV.

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