FADHILA IRAWATI, 051311133251 (2017) UJI AKTIVITAS ANTASIDA DAN ANTIFLATULEN SEDIAAN SIRUP EKSTRAK ETANOL RIMPANG KENCUR (Kaempferia galanga Linn) SECARA IN VITRO. Skripsi thesis, Universitas Airlangga.
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Abstract
The purposes of the present study are to evaluate the antacid and antiflatulent activities of ethanol 70% extract of Kaempferia galanga rhizome in vitro by using a modified artificial stomach model. In the evaluation of antacid activity, a modified model of Vatier’s artificial stomach was used to determine the duration of neutralization of the artificial gastric acid. The neutralization was determined by using the classical titration method. While the antiflatulent activity test was performed by observing the ability of samples to minimize foam in the artificial stomach model for 20 minutes. The positive control used in antacid activity test was antacid suspension containing aluminum hydroxide and magnesium hydroxide, while in antiflatulent activity test was dimethylpolysiloxane. The negative control was syrup without extract. The concentration of samples used were 1%, 1,5%, and 2% The results showed that the observed neutralization time were 0,51 ± 0,06 min for negative control, 36,20 ± 0,97 min for formula 1, 77,53 ± 2,14 min for formula 2 and 98,32 ± 0,95 min for formula 3. The data then analyzed by One way annova method continued with Post hoc test. The results of antacid activity showed that there were significant difference between control negative and the formula groups. The results of the antiflatulent activity test for negative control was 1,8 ± 0,2 cm, while the formula 1, 2 and 3 were 1,0 ± 0,1 cm, 0,7 ± 0,1 cm, and 0,7 ± 0,0 cm respectively. Data analysis was done by one way annova method followed by Post hoc test of LSD test method (α= 0,05). The results indicated that there were significant difference between control negative and the formula groups.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK2 FF.FT.24/17 Ira u | |||||||||
| Uncontrolled Keywords: | Kaempferia galanga Linn, rhizome, syrup, antacid, antiflatulent, modified artificial stomach model, in vitro | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | |||||||||
| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | |||||||||
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| Depositing User: | Mr Binkol1 1 | |||||||||
| Date Deposited: | 28 Dec 2017 19:05 | |||||||||
| Last Modified: | 17 Jan 2018 20:07 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/65140 | |||||||||
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