MITA AYU MARATIKA, 051311133044 (2017) UJI AKTIVITAS ANTITUSIF EKSTRAK ETANOL 70% RIMPANG JAHE MERAH (Zingiber officinale Roscoe var. rubrum) DALAM SEDIAAN SIRUP SECARA IN VIVO. Skripsi thesis, Universitas Airlangga.

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Abstract

Zingiber officinale Roscoe (ginger) have long been used as traditional medicine to relieve cough. The purpose of this research is to determine antitussive activity of ethanolic extract of Zingiber officinale var. rubrum (red ginger) rhizhome in syrup formulation using mice animal model. Mice was administered with 0.2 ml/kgBW of syrup extract, 60 minutes prior to placed into 1000 ml chamber and induced with 0.3 ml of 25% ammonium hydroxide solution for 45 seconds. The cough frequency was observed and measured for 5 minutes without removing the mice from the chamber. Codeine phosphate (30mg/kgBW) was used as positive control. The results of this research showed that the etanolic extract of red ginger rhizome in syrup formulation has activity to inhibit frequency of cough significantly (p<0.05) as the dose increased. Ethanolic extract of red ginger rhizome in syrup formulation at doses 200, 400, and 600 mg/kgBW showed percentage of cough inhibition 14.8%; 34.5%; and 45.9% respectively after 60 minutes of drug administration. The highest dose of 600 mg/kgBW was found to be more effective. In conclusion ethanolic extract of red ginger rhizome in syrup has activity to inhibit cough.

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