YUNITA CAHYANI, 0513111330190 (2017) PENENTUAN KADAR KOLESTEROL PADA PEMBERIAN SERBUK PORANG (Amorphophallus onchophyllus) DAN SERBUK KONJAK(Amorphophallus konjac) TERSTANDAR GLUKOMANAN PADA MENCIT PUTIH (Mus Musculus). Skripsi thesis, Universitas Airlangga.
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Abstract
The major component of porang and konjac powder from porang tuber (Amorphophallus oncophyllus) and konjac powder (Amorphophallus konjac) was glucomannan. Glucomannan can reduce cholesterol level by forming gel and expanding in the stomach, thus results in the slow lipid absorption and reduce cholesterol levels. Porang and konjac powder that had been standardized with its level of glucomannan was used as sample. The level of glucomannan obtained porang powder was 53,33±0,74 (%,b/b) while glucomannan level of konjac powder was 61,24±0,61 (%,b/b).This study consisted of 8 treatment groups contained male mice aged 2-3 months. Those mice were induced with mixture of high-cholesterol diet (lard: duck egg yolk) and PTU 0,1% and the cholesterol level was checked 3 days after the induction (pretest) and continue to be checked up to 21 days. Treatment groups consisted of negative control (CMC Na 0,3%), positive control (Simvastatin), treatment group I, II, III, IV, V, VI with the administration of porang powder standard glukomannan dose of 85; 165; 250 mg/ kg body weight of mice and konjak powder standard glukomannan dose of 85; 165; 250 mg/ kg Body weight of mice.The treatment was administered up to 21 days with cholesterol checking in day 7, 10, 14 and 21. The results were analyzed with oneway ANOVA (significant value of 5%). The analyzed results indicated that glucomannan standardized konjac powder with dose of 250 mg/kg body weight can reduce cholesterol levels in mice significantly after 7 days of administration (sig<0,05).
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK2 FF.KF.29/17 Cah p | |||||||||
| Uncontrolled Keywords: | (Amorphophallus oncophyllus), (Amorphophallus konjac) cholesterol, glucomannan, porang, porang tuber, konjac, konjac tuber. | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | |||||||||
| Divisions: | 05. Fakultas Farmasi > Kimia Farmasi | |||||||||
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| Depositing User: | Mr Binkol1 1 | |||||||||
| Date Deposited: | 28 Dec 2017 19:22 | |||||||||
| Last Modified: | 17 Jan 2018 21:05 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/65262 | |||||||||
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