NURMELINDA HADI NINGRUM, 051311133220 (2017) PENETAPAN KADAR ASAM URAT DENGAN PEMBERIAN EKSTRAK DAUN SIRSAK (Annona muricata L.) TERSTANDAR KUERSETIN PADA MENCIT PUTIH (Mus musculus). Skripsi thesis, Universitas Airlangga.

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Abstract

Various morphological parts of Annona muricata Linn are widely used medicinally in many parts of the world including lowering uric acid level by its leaves. Previous study reported that quercetin contains in Annona muricata Linn leaves extract showed the ability to reduce uric acid level in hyperuricemic condition. Quercetin as mayor compound in Annona muricata Linn leaves extracted and determine by using Spectrophotometer UV. Quercetin concentration in leaves extract was 13,04±1,60) % (w/w). Hyperuricemic mice induced by potassium oxonate 7,0 mg/20g BW mice i.p. The mice were treated in six groups for 21 days, negative control group (CMC Na 0,3% solution), positive I group (quercetin 0,39 mg/20g BW mice), positive II group (allopurinol 0,26 mg/20g BW mice) and three test groups contains standarized quercetin 0,13 mg/20g BW, 0,39 mg/20g BW, 0,65 mg/20g BW mice orally. The uric acid level and body weight were analyzed by One Way Anova and Paireed t Test. The results is that test group with dose contains standarized quercetin 0,65 mg/20g BW mice can decrease uric acid levels significantly for 13 days with tan α=0.2472. The activity study showed that Annona muricata Linn extract standarized quercetin did not effect the change of body weight.

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