ILHAM PANDIKA HARIS CHANDRA, 05131133200 (2017) OPTIMASI METODE UJI DISOLUSI NANOKRISTAL HESPERETIN. Skripsi thesis, Universitas Airlangga.

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Abstract

Hesperetin is an aglycon of flavanone glycoside hesperidin, which is poorly soluble in water. This poorly soluble characteristic becomes a hindrance in the absorption of hesperetin when given orally, particularly due to the slow dissolution rate of this compound. One of the strategies which can be applied to overcome this problem is by formulating hesperetin as nanocrystals. In this study, hesperetin has been formulated into nanocrystal using poloxamer 407 as the stabilizer. Preparation of nanocrystals was conducted using wet ball milling method. With regard to the dissolution assay, up to now there is no compendial method has been established for the dissolution test of nanocrystals particularly hesperetin. The aim of this research was to develop dissolution test method of nanocrystal hesperetin with standard phosphate buffer pH 6.8 as the dissolution medium. A non-ionic surfactant, Tween® 80, was added into phosphate buffer pH 6.8 to meet sink condition. Dissolution test was carried out at two different stirring speeds: 50 rpm and 100 rpm. The results showed that there was no significant difference between hesperetin nanocrystals dissolution profile at stirring speed 50 rpm and 100 rpm.

Item Type:	Thesis (Skripsi)
Additional Information:	KKB KK2 FF.F.31/17 Cha p
Uncontrolled Keywords:	Hesperetin, Poloxamer 407, Nanocrystals, Dissolution
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	05. Fakultas Farmasi > Farmastika
Creators:	Creators NIM ILHAM PANDIKA HARIS CHANDRA, 05131133200 UNSPECIFIED
Contributors:	Contribution Name NIDN / NIDK Thesis advisor Retno Sari, Dr. , M.Sc., Apt UNSPECIFIED Thesis advisor Maria L. A. D. Lestari, Dr.rer.nat. , Apt UNSPECIFIED
Depositing User:	Mr Binkol2 2
Date Deposited:	27 Dec 2017 20:05
Last Modified:	27 Dec 2017 20:05
URI:	http://repository.unair.ac.id/id/eprint/65483
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