APRILIANA LUTFIA, 051311133180 (2017) AKTIVITAS ANALGESIK PADA KOMPLEKS INKLUSI ASAM PARAMETOKSISINAMAT(APMS)- HIDROKSIPROPIL β-SIKLODEKSTRIN (Dibuat dengan Metode Microwave Irradiation). Skripsi thesis, Universitas Airlangga.

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Abstract

Para methoxycinnamic Acid (pMCA) is a semi-synthetized substance from Kaempferia galanga linn. rhizome with analgesic activity but poor solubility in water. In an effort to improve the solubility of pMCA, a 1:1 complex inclusion was prepared with pMCA and hydroxypropyl β- cyclodextrin. The method used in this complex is microwave irradiaton. The aims of this study was to compare analgesic activity of inclusion complex between (pMCA) and (HPβCD) prepared by microwave irradiation method with APMS and physical mixture. Writhing test is the method that used in the research. Analgesic activity represented by decreased frequency of writhing with the presence of analgesic drug. The result showed that inclusion complex between (pMCA) and (HPβCD) prepared by microwave irradiation method had better analgesic activity when compared to pMCA but not when compared to physical mixture.

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