Nurita Alami D.W, dr, NIM011181111 (2017) LAJU PERTUMBUHAN JANGKA PENDEK DAN KADAR FEKAL IgA SEKRETORIK PADA BAYI KURANG BULAN YANG MENDAPATKAN ASI ATAU ASI YANG DIFORTIFIKASI DENGAN HMF. Thesis thesis, Universitas Airlangga.

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Abstract

Extrauterine growth restriction (EUGR) is a common problem and related to neurodevelopmental outcome. Independent risk factor of EUGR is necrotizing enterocolitis (NEC). Concentration secretory IgA (sIgA) as main immunity system decreased by age. Human milk fortification may resolved EUGR and organ imaturity of preterm baby. Aim : Analyzed difference gain velocity and sIgA fecal between preterm baby received human milk and human milk fortified. Methode : Prospective analytic observational study between December 2015-July 2016 at Soetomo hospital Surabaya. Inclusion criteria consisted of gestational age ≤ 34 weeks and birth weight 1000 till less than 2000 g. Multiple congenital anomaly and enteral nutrition avoidance as exclusion criteria. Indication human milk fortification were stabile periode, no suckling reflex and gain weight velocity (GWV) <10 g/kgbw/d. Preterm baby were recruited and followed in 14 days. Chi-square, Mann whitney and t-test independent sample used to analyzed discrepancies GWV, gain length velocity (GLV), gain head circumferrence velocity (GHC) and sIgA fecal. Result : Human milk fortification (22(12,86-51,76) g/kgbw/day) showed significance difference to GWV than human milk (14,28(-12,86-(+32,86)) g/kgbw/d) group (p=0,020). GLV(p=0,257), GHC (p=0,215) and sIgA fecal (p=0,418) revealed no difference. Side effects (feeding intolerance and NEC) not found during observation. Conclusions : Human milk fortification showed higher GWV than human milk group. Follow up still needed to evaluated anthropometric parameter.

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