Siti Haifa Nur Jannah, NIM011311133087 (2017) UJI EFEKTIVITAS EKSTRAK DAUN PETAI (Parkia speciosa hassk) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS WISTAR JANTAN (Rattus Novergicus L.) YANG DIINDUKSI STZ (Streptozotocin). Skripsi thesis, Universitas Airlangga.

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Abstract

Background : Diabetes mellitus prevalence is ever increasing year to year, that an effective and efficient drug is needed to overcome this metabolic syndrome. This research uses Parkia Speciosa hassk be an effective and economic traditional alternative as it contains flavonoid, terpenoid, tannin,and phenolic that are capable of lowering glucose level. Purpose : To analyze the effects of Parkia Speciosa hassk extract administration on the glucose level reduction in streptozotocin – induced male wistar rat. Method : It is an experimental research using the pre and post test randomized controlled group design. Experimental animals are 30 male wistar rat divided into 5 treatment groups; pure water (negative control), metformin dose of 18 mg/200g of bodyweight (positive control), and three groups given 125, 250, 500 mg/kg of bodyweight Parkia Speciosa hassk extract respectively. Each group has been induced with streptozotocin to a glucose level of approximately 126 mg/dL, and then their post streptozotocin fasting glucose level is measured as pre test data. Treatments are administered for 7 days, and during 7 their fasting glucose levels are measured as post test data. Results : In the treatment group a dose of 125 mg / kg bodyweight,The remaining number of samples is too small until the end of the research, So that results can not be determined. But,treatment groups with dose 250 and 500 mg/kg of bodyweight indicate significant values at pre test and post test, with p < 0.05. Dose 250 and 500 mg/kg of bodyweight show better reduction compared to using pure water and shows equivalent reduction to using metformin generally in 7 days. Conclusion : Parkia Speciosa hassk extract with dose 125 mg/kg bodyweight that results can not be determined. But, Parkia Speciosa hassk extract with dose 250 and 500 mg/kg of bodyweight has the ability to lower glucose level better than pure water and effective as metformin if admistered for 7 days.

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