Zulfiatul Khiftiannisa’, NIM011311133085 (2017) PENGARUH PEMBERIAN EKSTRAK KEMANGI (Ocimum sanctum L.) TERHADAP DERAJAT KERUSAKAN MUKOSA GASTER MENCIT (Mus musculus) YANG DIINDUKSI ASPIRIN. Skripsi thesis, Universitas Airlangga.
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Abstract
Introduction: Long-term uses in high-dose therapy of aspirin causes gastric mucosal damage. Herbs which known has flavonoid compounds as gastroprotective is Ocimum sanctum L.. Objectives: This study aimed to determine the effect of extracts of Ocimum sanctum L. on the degree of mice (Mus musculus) gastric mucosal damage induced by aspirin. Material and methods: This experimental research used post-test only control group design. Thirty male mice average weight 20-30 grams were divided into 5 groups. Four groups (KP, P1, P2 and P3) were induced by aspirin 56 mg/kgBW for 7 days. One group (N) was administered with CMC Na 0,5% for 14 days. Group P1, P2, and P3 was administered with extract of Ocimum sanctum L. dosage 28, 42, and 56 mg/kgBW on day 8-14. All treatments were given per oral, once a day. The whole group was terminated on day 15, except KP which terminated on the 8th day. Gastric fundus was taken for Hematoxylin eosin staining (HE) and observed under a microscope, magnification of 400x in 5 visual fields to assess the degree of gastric mucosal damage by Esplugues & Whittle scoring system. Statistical analysis was done with Kruskal-Wallis and Mann-Whitney test. P value of <0.05 was considered statistically significant. Results: There was significant differences between the positive control group and treatment group 1 (p= 0.011). Positive control group shown 0% normal mucosa and dominated with third-degree damage while the treatment group 1 shown 20% normal mucosa and dominated with second-degree damage. Conclusion: It was only 28 mg/kgBW extract of Ocimum sanctum L. group which shown significant gastroprotective effect of gastric mucosal damage compared with positive control group.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKA KK FK.PD.68/17 Khi p | |||||||||
| Uncontrolled Keywords: | gastric mucosal damage, Ocimum sanctum, aspirin, gastroprotective, anti-ulcer | |||||||||
| Subjects: | R Medicine > RV Botanic, Thomsonian, and eclectic medicine | |||||||||
| Divisions: | 01. Fakultas Kedokteran | |||||||||
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| Depositing User: | Mr Binkol2 2 | |||||||||
| Date Deposited: | 01 Jan 2018 22:45 | |||||||||
| Last Modified: | 01 Jan 2018 22:45 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/66253 | |||||||||
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