RESTRY SINANSARI, 051224153009 (2017) PENGARUH EKSTRAK ETANOL 70% TERFRAKSINASI, EKSTRAK ETANOL 70% DAN EKSTRAK AIR DAUN GANDARUSA (Justicia Gendarussa Burm. f) TERHADAP STIMULASI PEMBENTUKAN INTERFERON α, β, DAN γ PADA MENCIT (Mus musculus) (Studi Pengembangan Anti Human Immunodeficiency Virus (HIV)). Thesis thesis, Universitas Airlangga.

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Abstract

Justicia gendarussa Burm f. (Achanthaceae) has been known as traditional medicinal in Indonesia. Nowadays an anti-HIV drugs are developed from Justicia gendarussa Burm. f. The previous research proved that the major compound of 70% ethanol extract, flavonoid apigenin glycoside called Gendarusin A was reported has the ability to inhibit the growth of virus in the blood plasma of patients with HIV (Prajogo et al., 2010). This research was conducted to identify the effect of the 70% ethanol extract, fractionated-70% ethanol extract, and water extract of J. gendarussa leaves on the profile of interferon α, β, and γ stimulation on mice (Mus musculus). The test was established by giving the eleven groups of mice with gandarusa extract. The dossage of 70% ethanol extract and fractionated-70% ethanol extract given on 3 groups of mice on each group was 2,23 g/kgBW; 1,11 g/kgBW dan 0,57 g/kgBW and on the group of water extract 1,954 g/kgBW; 0,977 g/kgBW; 0,489 g/kgBW dossage was given to each group. Through this research, it is known that the fractionated-70% ethanol extract did not increase the levels of IFN-α, IFN-β and IFN-γ of mice. While the both of water extract and 70% ethanol extract of J. gendarussa leaves do not induce the IFN-α and IFN-β but have the effect of IFN-γ inducer at 1.11 g/kgBW and 2.23 g/kgBW for the 70% ethanol extract and 0.98 g/kgBW and 1.95 g/kgBW for the water extract.

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