Teresa Tiffani Thomas, NIM011411133010 (2017) POLA HASIL PEMERIKSAAN IMMUNOPHENOTYPING KASUS LEUKEMIA AKUT PADA PASIEN DEWASA DI RSUD DR. SOETOMO JANUARI 2012 – JUNI 2017. Skripsi thesis, Universitas Airlangga.

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Abstract

Background : Leukemia is a type of cancer that attacks blood cells, especially the white blood cells. There are two types of predominant cell involved, lymphoid and myeloid. The formation of blood cells begins with stem cells that differentiate and proliferate following a specific lineage. Immunophenotyping is one of the methods used to determine the leukemia type. There are 247 cluster of differentiation (CD) expressed by the membrane plasma which represent precursors in the maturation stages of leukocytes (Belov et al, 2006). Researchers conducted observations on CD and specific markers found in each type of acute leukemia of adult patients in RSUD Dr. Soetomo. Method : This is a descriptive retrospective research observing the pattern in immunophenotyping results, including markers and aberrant of adult acute leukemia patients. The study also included sociodemography (sex and age) and the frequency of each diagnosis. Results : Out of 238 samples, the most common diagnosis is AML (73.11%), followed by ALL B lymphoid (21.85%) and ALL T lymphoid (5.04%). The most common marker for AML is the combination of CD33 and CD13 (70.11%). The most common marker for ALL B lymphoid is the combination of CD19, CD20, CD10, and CD79a (52.94%) and for ALL T lymphoid is the combination of CD3, CD5, and CD7 (66.67%).

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