Felicia Jiwantono, NIM011411131060 (2017) UJI EFEKTIVITAS EKSTRAK BUNGA KAMBOJA (Plumeria alba) SEBAGAI ANTIBAKTERI TERHADAP Streptococcus pyogenes. Skripsi thesis, Universitas Airlangga.

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Abstract

Introduction: Infection is one of the health issues which is caused by pathogenic microorganisms and one of the most common microorganism is Streptococcus. There are 616 pharyngitis cases that are caused by Streptococcus pyogenes worldwide. The disease can lead to other complications if it is not treated well. In addition, treatment using antibiotics has a risk of resistance. Therefore, it is necessary to develop research on herbals as treatment. The white Frangipani flower (Plumeria alba) is known to have antimicrobial activity against various microorganisms. Based on this background, the aim of this study is to determine the antimicrobial activity of Plumeria alba against Streptococcus pyogenes that can be observed through the MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration). Methods: This research was done through a true experimental method. Agar dilution method is used to determine the MIC and MBC. The concentrations used in this research are 250 mg/ml, 125 mg/ml, 62.50 mg/ml, 31.25 mg/ml, 15.63 mg/ml, 7.81 mg/ml, 3.91 mg/ml, 1.95 mg/ml, 0.98 mg/ml, positive control (+) and negative control (-). Results: Through the observation of the research, the MIC cannot be determined. The value of MBC is 7.81 mg/ml which indicate the minimum concentration when there is zero growth of the bacteria colony. Conclusion: Ethanol extract of the white Frangipani flower (Plumeria alba) has antimicrobial activity against Streptococcus pyogenes. In this in vitro study using agar dilution method, the MBC for Streptococcus pyogenes is at 7.81 mg/ml.

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