Kintan Putri Resvaldy Kania, NIM011411131099 (2017) NILAI DIAGNOSTIK CA-125 PADA PASIEN KANKER OVARIUM JENIS EPITELIAL TAHUN 2016 DI RSUD DR. SOETOMO SURABAYA. Skripsi thesis, Universitas Airlangga.

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Abstract

Background: Based on findings by Cancer Country Profiles (WHO, 2014), ovarian cancer is the fourth cancer with most incidence in Indonesian female with 10.238 cases in 2014 (WHO, 2014). Tumor marker CA-125 is assosciated with ovarian cancer, importantly epithelial ovarian cancer. Purpose: To find diagnostic value (sensitivity, specificity, positive predictive value, negative predictive value) of CA-125 among patients with epithelial ovarian cancer in Dr. Soetomo General Hospital Surabaya in 2016. Method: This study is analytic cross sectional and was performed by evaluating medical records of patients suspected for ovarian malignancy in Dr. Soetomo General Hospital Surabaya in 2016. Results: There were total 97 patients found fit for criteria of inclusion in this study. Tissue histopathological examination confirmed 66 patients have epithelial ovarian malignancy and 31 patients do not. Samples distributed using 35 U/ml as CA- 125 upper limit, TP: 54.64%, FP: 19.59%, FN: 13.40%, dan TN: 12.37%. Diagnostic value obtained as follows: sensitivity 80.30%, spesificity 38.71%, positive predictive value 73.61%, negative predictive value 48%, and accuracy 67.01%. Conclusion: Tumor marker assosciated with ovarian cancer CA-125 has found high in sensitivity but low in specificity among patients with epithelial ovarian cancer in Dr. Soetomo General Hospital Surabaya in 2016.

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