Estya Nadya Meitavany, NIM011411131143 (2017) UJI EFEK ANALGESIK MINYAK ATSIRI RIMPANG LEMPUYANG WANGI (Zingiber aromaticum) PADA MENCIT. Skripsi thesis, Universitas Airlangga.

ABSTRAK_FK.PD.455 17 Mei u.pdf

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Introduction: Zingiber aromaticum is used as traditional medicine to reduce pain (Handayani, 1994). Zerumbone and caryophyllene oxide contained in essential oil of Zingiber aromaticum has analgesic effect (Respati, 2010). Zerumbone inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), and production of nitric oxide (NO) dan prostaglandin E2 (PGE2) (Chien et al., 2016). This study aims to observe analgesic effect of essential oil of Zingiber aromaticum using hot plate test Method: Essential oil was extracted from Stahl distillation. Twenty five mice were acclimatized for a week then divided into 5 groups. Each group was given DMSO 10%, essential oil at the dose of 0,1 mL/kg, 0,2 mL/kg, 0,4 mL/kg, and acetyl salicylic at the dose of 13 mg/20 g. Latency period was measured every 5 minutes for an hour. Result: Statistical analysis shown significant difference in minute 15 (p = 0,012), 55 (p = 0,02), dan 60 (p = 0,02). Latency period is not related to dose of essential oil. This may be caused by hot plate test sensitivity to COX inhibitor, variance of mice responses, and mice learning to repeated exposure from hot plate test. Conclusion: There is no analgesic effect of essential oil of Zingiber aromaticum.

Item Type: Thesis (Skripsi)
Additional Information: KKA KK FK.PD.455/17 Mei u
Uncontrolled Keywords: Hot plate test, essential oil, Zingiber aromaticum
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA421-790.95 Public health. Hygiene. Preventive medicine > RA428-428.5 Public health laboratories, institutes, etc.
Divisions: 01. Fakultas Kedokteran
Estya Nadya Meitavany, NIM011411131143NIM011411131143
ContributionNameNIDN / NIDK
Thesis advisorSri Purwaningsih, dr., M.Kes.UNSPECIFIED
Thesis advisorDamayanti Tinduh, Dr., dr., Sp.KFR-K.UNSPECIFIED
Depositing User: Mrs Nadia Tsaurah
Date Deposited: 21 Dec 2017 19:02
Last Modified: 21 Dec 2017 19:02
URI: http://repository.unair.ac.id/id/eprint/68609
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