FITRIA NUGRAHAENI, 051514153001 (2018) PENGEMBANGAN FORMULA MIKROSFER ALGINAT UNTUK MENINGKATKAN EFEKTIVITAS DAN STABILITAS GLUTATION. Thesis thesis, Universitas Airlangga.

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Abstract

Glutathione (GSH) is a broad antioxidant of the thiol-tripeptide group, highly hydrophilic, that made it is not possible for topical preparations. A lipophilic surfactant is used to enhance the glutathione partition coefficient. The purpose of this study was to determine the apparent partition coefficient (APC log) of glutathione; glutathione with addition of surfactant at HLB 4.3; 5.5; 7; 11; 13 to formulate and evaluate characteristics, the stability of the glutathione and dried glutathione surfactant HLB 7 loaded alginate microspheres, and to measure effectivity using an MMP-1 parameter. . The study was conducted by dissolving glutathione in water and addition of HLB surfactants. Determination method of partition coefficient was done by shake flash method. Microspheres were characterized for the morphology and size, drug loading, entrapment efficiency, yield, accelerated stability, and effectivity using the MMP-1 parameter on mouse skin. The results showed thar partition coefficient of glutathione increased and enhanced their lipophilicity. In addition, the stability increased by forming glutathione in the microspheres compared to without microspheres. To conclude both dried glutathione surfactant HLB 7 loaded alginate microspheres and glutathione surfactant HLB 7 demonstrated potential for topical delivery system

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