M. FATCHUR ROCHMAN, 051424153001 (2018) OPTIMASI PROSES PEMBUATAN NANOSTRUCTURED LIPID CARRIER UBIQUINONE 10 DENGAN METODE HIGHSHEAR HOMOGENIZATION. Thesis thesis, Universitas Airlangga.

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Abstract

10 can increase the production of basal membrane components, fibroblast proliferation and protect cells from oxidative damage, so with increasing age, the amount of Ubiquinone-10 body will decrease. The bioavailability and permeability of Ubiquinone-10 are very low, thus affecting the potential efficacy and absorption in Ubiquinone-10. The preparation of the Ubiquinone-10 formulation needs to be done to obtain products that have good bioavailability. Nanostructured Lipid Carrier (NLCs) is a modification of the SLN system, consisting of a certain amount of lipid matrix and liquid lipids. Mixtures of solid lipids and liquid lipids can provide space for drug trapping efficiency. The system will remain in solid form by controlling the concentration of the liquid lipids to be added into the formula so that the drug release process can be controlled This study was conducted to determine the process of manufacturing optimal NLC with Ubiquinone-10 as the active ingredient. The manufacturing process has an effect on the physical characteristics of the NLC mixture. Optimization of NLC manufacturing process used High-Shear Homogenization technique to predict comparison of mixing time and speed of to produce good characteristic. Mixtures of NLC consist of Ubiquinone-10, Cetyl Palmitate, alpha-tocopherol acetate, Tween 80 and propylene glycol. The NLC formulation process is done by comparing mixing time and speed. The highest speed and mixing time results in the best physical characteristics of NLC, the higher % Entrapment Efficiency and smaller particle size.

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