Dimas Luthfi Razantira, NIM011111243 (2018) PENGARUH PERBEDAAN WAKTU TIDUR DENGAN INDUKSI DIAZEPAM TERHADAP KADAR GLUKOSA DARAH PERIODE AKTIVITAS DAN PERIODE ISTIRAHAT MENCIT (Mus musculus). Skripsi thesis, Universitas Airlangga.

Preview	Text (abstrak) abstrak.pdf Download (250kB) | Preview
	Text (full text) full text.pdf Restricted to Registered users only until 15 March 2021. Download (2MB)

Abstract

Several studies have indicated the widespread effect of sleep and sleep pattern to several endocrine functions throughout the body. Among these multiple endocrine processes, cortisol and liver activity are some of the functions that may directly alter the blood glucose level. For people with or without a sugar metabolism related disorder, an irregularity of the blood glucose level may affect their daily performance and productivity. With the rising trend of irregular sleep pattern throughout the population, more researches regarding the sleep-wake mechanism and its effects on the blood glucose regulations are required. This study used 24 mice (M. musculus), which were divided among 4 groups based on the starting time of their resting periods using the induction of 0.004 mg diazepam delivered orally for 14 days. All four groups, are then tested for their non-fasting blood glucose level per 4 hours for 3 x 24 hours. While the comparation, analyzed with a mean comparison, between the groups doesn’t show similarity between the 4 groups active and resting period glucose level, a paired t-test of the 2nd experimental group (resting periods start time at 15.00 GMT +7) shows a significant difference (p = 0.00) between the active and resting periods. The group shows a higher resting period blood glucose level (averaged at 170.74 mg/dL) than the active period blood glucose level (averaged at 150.14 mg/dL). Further studies are required to analyze the cause of this anomaly

Actions (login required)

View Item