WINDA PUTRI PRATAMA, 051211133005 (2018) UJI AKTIVITAS ANALGESIK SENYAWA 4-NITROBENZOIL-3-ALILTIOUREA PADA MENCIT (Mus musculus) DENGAN METODE WRITHING TEST. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Synthesis of 4-nitrobenzoyl-3-allylthiourea was accomplished by acylated allylthiourea with 4-nitrobenzoyl chloride. The acylation procedure based on Schotten-Baumann reaction modification triethylamine as a base and a catalyst. The percent yield of the product of synthesis was 28%. The purity of the compound was analyzed by Thin Layer Chromatography and melting point test. According to the UV-Vis and FT-IR spectra analysis, it showed that 4-nitrobenzoyl-3-allylthiourea was successfully synthesized. Analgesic activity of the compound was tested in mice (Mus musculus) using writhing test method with 0,6% acetic acid as the pain inducer. The doses of the 4-nitrobenzoyl-3-allylthiourea are 10 mg/KgBW, 20 mg/kgBW, and 40 mg/KgBW was given in mice by intraperitoneal injection. The result of ED50 for 4-nitrobenzoyl-3-allylthiourea is 12,5 mg/Kg body weight, for allylthiourea is 21,87 mg/Kg body weight, and for diclofenac natrium is 14,79 mg/Kg body weight. Statistically, the analgesic activity of 4-nitrobenzoyl-3-allylthiourea was higher compare with allylthiourea and diclofenac natrium.
Item Type: | Thesis (Skripsi) | |||||||||
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Additional Information: | KKB KK-2 FF.KF. 04-18 Pra u | |||||||||
Uncontrolled Keywords: | analgesic activity test, 4-nitrobenzoyl-3-allylthiourea, writhing test method | |||||||||
Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica | |||||||||
Divisions: | 05. Fakultas Farmasi > Kimia Farmasi | |||||||||
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Depositing User: | Tatik Poedjijarti | |||||||||
Date Deposited: | 18 Mar 2018 17:06 | |||||||||
Last Modified: | 18 Mar 2018 17:06 | |||||||||
URI: | http://repository.unair.ac.id/id/eprint/70922 | |||||||||
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