SURYO KUSUMA PRADANA, 051311133169 (2017) VALIDASI METODE FLAME ATOMIC ABSORPTION SPECTROPHOTOMETRY (FAAS) UNTUK PENETAPAN KADAR MINERAL (Cu, Fe, dan Mn) DALAM SEDIAAN KAPSUL MULTIVITAMINMINERAL. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purpose of this present study is to validate the Flame Atomic Absorption Spectrometry (FAAS) for the determination of minerals contained in the multivitamin-mineral capsule such as Cu (copper), Fe (iron), and Mn (manganese). The sample is destructed through destruction process of dry ashing (550 ± 20° C for 2 hours until in ashes form) then continued to wet ashing by using mixture of 6 M HCl and concentrated HNO3 (25:1). The validation of the method comprises the selectivity, linearity, limit of detection (LOD, limit of quantification (LOQ), precision, and accuracy. The proposed method has concentration ranges of 0.49 – 1.99 μg/ml for Cu, 1.99 – 9.99 μg/ml for Fe, and 0.50 – 2.01 μg/ml for Mn. The correlation coefficient (r) obtained for each linearity equations are higher than 0.999 with the relative process standard deviation value (Vxo) is not more than 5%. LOD are found to be 4.8×10-3 μg/ml for Cu, 6.2×10-2 μg/ml for Fe, and 1.7×10-2 μg/ml for Mn, meanwhile the LOQ are 0.01 μg/ml for Cu, 0.1865 μg/ml for Fe, and 0.05 μg/ml for Mn. The method was successfully applied for the determination of the minerals e.g. Cu, Fe, and Mn in Multivitamin-mineral capsule dosage form.

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