RISA ETIKA, 090810563D (2018) TOLERAN PADA MENCIT NEONATUS BALB/c SETELAH PAPARAN ALERGEN PADA INDUK BUNTING (Kajian toleran terhadap ekspresi sitokin IL-2, IFN-. Disertasi thesis, Universitas Airlangga.

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Abstract

Background : Allergy is a health problem that increasingly need attention. Prevention efforts still have not managed to improve the disease satisfactorily. Meanwhile in–utero prevention efforts based on immunologies comprehension remains unclear. Research on tolerance in newborn Balb/c mice after exposing with allergens on pregnant mice needs to be done. Aims : To explain the allergens exposure on pregnant Balb/c mice and its role to tolerance in newborn mice by measuring cytokines Th1, Th2, Treg and IgG-1, IgG-2a, IgG-2b, IgG3 subclass level and IgM, IgA, IgE. Methods : Research in Virology & Immunology Laboratory, Dept of Microbiology Veterinary Faculty Airlangga University. Experimental study post-test only control group design, using factorial design to asses the effect of allergens Mite, Cat Hair, Dog Hair, Chicken Albumin and Cow Milk Protein with low-dose and high dose on pregnant Balb/c and newborn mice to tested variables. Sixty Balb/c pregnant mices divided into intervention group and control. Blood sampling of pregnant Balb/c and newborn mice to assess Th1(IL-2, IFN-

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