SHENDY CANADYA KURNIAWAN, 061411131185 (2018) DIFFERENTIAL WHITE BLOOD CELL COUNTS OF FEMALE NEW ZEALAND WHITE RABBIT(Oryctolagus cuniculus) INJECTED WITH HEPATITIS B VACCINEFORMULATION BY BOOSTER METHOD. Skripsi thesis, Universitas Airlangga.

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Abstract

The aim of this research was to determine the white blood profile especially the differential white blood cell counts (total leukocyte, lymphocytes, monocytes and granulocytes) of female New Zealand White rabbit (Oryctolagus cuniculus) injected with hepatitis B vaccine formulation by booster method. There were 12 rabbits that divided into 4 groups consist of 1 control group, and 3 treatment groups with different dose of vaccine formulation. Before the treatment, the rabbits had been adapted in new environment for 7 days in Experimental Animal Laboratory of Faculty Of Veterinary Medicine Airlangga University, given feed and water ad libitum daily. After adaptation period, all treatment rabbits had the vaccination at day 0. Control group was given PBS 0.4ml injected intramuscular via 4 legs, 0.1ml for each leg and treatment groups were given hepatitis B Vaccine formulation 0.4ml injected intramuscular via 4 legs, 0.1ml for each leg. Then boosters were done at day 30 and 60 with the same vaccine formula and dose with day 0. Post treatment blood sample were collected at day 75, the blood was collected via intracardial and then analyzed by haematology analyzer.The post treatment result lead statistically non significant increase (p>0.05). It means the vaccine did not cause significant change in white blood cell counts and does not cause any illness and harmful effect such as leucocytosis or panleucopenia. Thats why the vaccine is safe to use.

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