ALISSA DEVI AGUSTINA, NIM011218016307 (2018) PERBANDINGAN KLINIS DAN HISTOPATOLOGI ANTARA TERAPI MOXIFLOXACIN INTRAVITREAL DENGAN TERAPI KOMBINASI MOXIFLOXACIN DAN DEXAMETHASONE INTRAVITREAL PADA ENDOFTALMITIS STAPHYLOCOCCUS AUREUS (Studi Eksperimental pada Oryctolagus cuniculus). Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Objective: To compare the clinic and histopathology between intravitreal moxifloxacin therapy with intravitreal moxifloxacin and dexamethasone combination therapy on animal model Staphylococcus aureus endophthalmitis. Materials and methods: This experimental study was conducted under local ethical review board. A total 18 rabbits were induced endophthalmitis by injecting intravitreal 102 CFU Staphylococcus aureus. Six rabbits were injected intravitreal moxifloxacin, 6 rabbits were injected intravitreal moxifloxacin and dexamethasone, and the another 6 rabbits were injected intravitreal balanced salt solution as control. Evaluation were undergone to all rabbits clinically on day 1, day 2, day 3 and day 5 using clinical grading scale. At the end of study all rabbits in each group were sacrified. The eye were enucleated and processed with Haematoxylin Eosin staining for histological studies. Evaluation using histopathologic grading scale at day 5. Results: The mean score of Clinical grading scale of moxifloxacin group on the 1st and 2nd day was 11.333 and 16.333. The median of Clinical grading scale on the 3rd day, 5th day and Histopathologic grading scale were 18, 24.and 12.5. The mean score of Clinical grading scale of moxifloxacin and dexamethasone groups on 1st day and 2nd day were 17.8 and 22.4. The median of Clinical grading scale on the 3rd, 5th day and Histopathologic grading scale were 25, 26 and 12. Statistical analysis result showed there was no difference on clinical grading scale on the 1st, 2nd and 5th day. There was a difference between moxifloxacin therapy and combination therapy of moxifloxacin and dexamethasone on clinical grading scale on the 3rd day (p < 0.05). There was no difference in moxifloxacin therapy with combination therapy of moxifloxacin and dexamethasone on histopathologic grading scale Conclusion: Intravitreal moxifloxacin is effective in the treatment of Staphylococcus aureus endophthalmitis. The combination of dexamethasone to the antibacterial treatment does not affect the pathological outcome and clinically increase the inflammation more than intravitreal moxifloxacin alone.

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