Dyah Fitria Ratna Kusuma, 061411131069 (2018) EFEK PEMBERIAN EKSTRAK ETANOL DAUN JUWET (Syzygium cumini ) SEBAGAI TERAPI ADJUVANT TERHADAP JUMLAH SEL MIKROGLIA PADA OTAK MENCIT (Musmusculus) YANG DIINFEKSI Plasmodium berghei. Skripsi thesis, Universitas Airlangga.

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Abstract

This study is aimed to know the effect of juwet leaf extract as adjuvant therapy on microglia brain cell count on mice (Mus musculus) which infected by Plasmodium berghei. Twenty fivemice divided into fiveteen mice for three control groups namely K0, K1 and K2 which infected by Plasmodium berghei in the amount of 1x106 in 0,2 ml and ten mice for two treatment groups namely P1and P2 which infected by Plasmodium berghei in the amount of 1x106in 0,2 ml. The data were analyzed by univariated ANOVA using SPSS and followed with Turkey HSD test. The results of statistical analysis showed significant differencesmicroglia cell count of K1 group’s and P2 group’s, but there was no differences microglia cell count of K2 and P1 group’s. An increase of microglia cell count seen in K1 which infected by Plasmodium bergheiwithout therapy and decrease of microglia cell count seen in P2 which infected by Plasmodium bergheiwith therapy chloroquine and juwet leaf extract. There was no significant difference of microglia cells count between K2 which infected by Plasmodium berghei with therapy chloroquine and P1which infected by Plasmodium berghei with therapy juwet leaf extract.

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