EKA PUTRI FIRNANDA, 061411131067 (2018) PENGGUNAAN KELINCI SEBAGAI HEWAN COBA UNTUK UJI TOKSISITAS FORMULASI VAKSIN HEPATITIS B TERHADAP NILAI ERITROSIT DAN HEMATOKRIT. Skripsi thesis, Univeritas Airlangga.

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Abstract

This study aims to determine the effect of hepatitis B vaccine with different formulas towards the changes erythrocyte values and hematocrit of male rabbit (Oryctolagus cuniculus). Twelve male rabbits were randomly divided into four treatment groups. Group P1 (0.4 ml of hepatitis b vaccine formula type 1 by IM), group P2 (0.4 ml of hepatitis b vaccine formula type 2 by IM), P3 group (0.4 ml of hepatitis b vaccine formula type 3 by IM) and Group K (Controls) which given 0, 4 ml of PBS solution by IM. Treatment given on day 0 after adaptation for 7 days, then on day 14 performed anesthesia to take whole blood by intracardiac in male rabbits. The results of the data from the research tested statistical analysis usedone – wayAnalysis of Variance(ANOVA). Based on the results used SPSS 22 for windows the method used is statistical parametric one – wayAnalysis of Variance(ANOVA) and continued with multiple comparison tukey post hoc test. In the ANOVA test, showing that the probability value (Sig.)> 0.05, thus H0 was accepted, or there was no significant difference between control and treatment group.

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