Tanjung, Mulyadi and Fida Rachmadiarti and Saputri, Ratih Dewi and Tjahjandarie, Tjitjik Srie (2017) Mesucalophylloidin, a new isoprenylated 4-phenylcoumarin from Mesua calophylloides (Ridl.) Kosterm. Natural Product Research, 32 (9). pp. 1062-1067. ISSN 1478-6419

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Abstract

ABSTRACT A new isoprenylated 4-phenylcoumarin derivative, mesucalophylloidin (1) along with three known compounds, mammea A/BA cyclo F (2), calolongic acid (3) and isocalolongic acid (4) were isolated from the stem bark of Mesua calophylloides (Ridl.) Kosterm. Structures of all the compounds were elucidated using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1–4 were evaluated for their cytotoxicity against P-388 cells, showing that compound 1 gave moderate activity with IC50 6.26 μg/mL.

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