DIAN ARDIANA, NIM011217017311 (2018) PROFIL WNT1, Β-CATENIN, SEL PUNCA MELANOSIT DAN MELANOSIT FOLIKEL RAMBUT PADA REPIGMENTASI PERIFOLIKULER VITILIGO DENGAN PEMBERIAN NARROW BAND - ULTRAVIOLET B. Disertasi thesis, Universitas Airlangga.
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Abstract
Background : Melanocyte stem cells (MelSCs) have been identified in the lower permanent portion of hair follicle and associated with perifollicular repigmentation pattern of vitiligo after Narrow Band-Ultraviolet B (NB-UVB) therapy. Wnt1 and β- catenin have been associated with UVB induced pigmentation in mouse and hyperpigmented lesion commonly seen on sun-exposed areas. The increase of MelSCs in these two conditions suggested the role of Wnt1 in MelSCs differentiation, which increases the number of melanocytes. Purpose : To explain the profile of hair follicle Wnt1, β-catenin, MelSCs and melanocytes in NB-UVB induced vitiligo perifollicular repigmentation. Methods : This clinical pre-experimental study used one group pre test-post test design. The dose of 390 mJ/cm2 DermaPalTM Daavlin NB-UVB was given twice a week for 2 months to 18 vitiligo patients. Biopsy was undertaken in vitiligo areas involving hair follicle before and after therapy and was assessed by immunohistochemistry technique. Data was analyzed using SPSS. Results : There was a significant difference (p<0.05) of vitiligo area size, the number of cells expressing Wnt1, MelSCs, MelSCs expressing β-catenin, MelSCs proliferation, melanocytes, also melanoblast and melanocytes proliferation in hair follicle before and after NB-UVB irradiation. Conclusion : There was a change in the profile of hair follicle Wnt1, β-catenin, MelSCs and melanocytes in vitiligo perifollicular areas before and after NB-UVB therapy. The finding of increment of hair follicle Wnt1 and β-catenin expression after NB-UVB therapy became the novelty of this study and it could be used for further research in perifollicular repigmentation mechanism.
| Item Type: | Thesis (Disertasi) | |||||||||
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| Additional Information: | KKA KK Dis. K. 32-18 Ard p | |||||||||
| Uncontrolled Keywords: | melanocyte stem cells, NB-UVB, perifollicular repigmentation, vitiligo Wnt1/β-catenin | |||||||||
| Subjects: | R Medicine > RL Dermatology | |||||||||
| Divisions: | 01. Fakultas Kedokteran | |||||||||
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| Depositing User: | Tatik Poedjijarti | |||||||||
| Date Deposited: | 04 Oct 2018 12:38 | |||||||||
| Last Modified: | 04 Oct 2018 12:38 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/74355 | |||||||||
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