DIANTI IAS OKTAVIASARI, 101614153016 (2018) PENGARUH PEMBERIAN JUS BUNCIS (PHASEOLUS VULGARIS LINN) TERHADAP KADAR SOD, KADAR MDA DAN KADAR GLUKOSA DARAH (STUDI EKSPERIMEN PADA TIKUS PUTIH JANTAN STRAIN WISTAR MODEL STRES PSIKOLOGIS). Thesis thesis, Fakultas Kesehatan Masyarakat.

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Abstract

Psychological stress is often suffered people with body rhythm disorders, such as sleep disorders upside down. Psychological stress can trigger oxidative stress, and it can be overcome by increasing antioxidants. Beans as antioxidants are considered to reduce oxidative stress. The aims of this study were to examine the effect of beans juice on SOD levels, MDA levels and blood glucose levels in white male rats strain wistar exposured by psychological stress. This study was Randomized Post Test Only Group Design. There were 5 groups tested, normal and stress control group, and 3 treatment groups. Psychological stress exposure was given to disturb sleep pattern, so that the condition of experimental animals experiencing oxidative stress, then given beans juice dose of 4.5 gram for treatment group. The results showed that SOD levels in treatment group increased after the 1st hour of giving beans juice and increased maximally at 24 hours. MDA levels and glucose levels dropped during the first hour and persisted down until the 24th hour after giving beans juice. The effect of antioxidant flavonoids on beans decreases the amount of free radicals by scavenging mechanisms and increases endogenous antioxidants. Arginine in beans acts as a precursor to form Nitric Oxide (NO) as vasodilator of blood vessels which works to decrease oxidative stress. It can be concluded that single dose of beans juice in experimental animals has been shown to overcome oxidative stress due to psychological stress exposure since the first hour of giving beans juice and its antioxidant levels persisted until the 24th hour

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