KIAJENG WINDA NINGRUM PRINASETYA, NIM011328016304 (2018) PENGARUH TERAPI OKSIGEN HIPERBARIK TERHADAP PERBAIKAN DERAJAT METAMORFOPSIA MELALUI PERUBAHAN KETEBALAN INNER NUCLEAR LAYER DAN OUTER NUCLEAR LAYER MAKULA PADA PENDERITA AGE RELATED MACULAR DEGERATION TIPE KERING. Thesis thesis, Universitas Airlangga.

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Abstract

Objective : Prove the effect of hyperbaric oxygen therapy on the improvement of metamorfopsia degree, change in macular inner and outer nuclear layer thickness in dry type AMD patients stage 1, 2 and 3 based on AREDS classification. Methods : This was experimental study with pre0test and post-tes control group design. The subject included were AMD dry type patient who admitted to retinal devision outpatient clinic. They were divided into two groups. The treatment group administered oxygen hyperbaric therapy and antioxidant tablet, and the control group administered antioxidant tablet only. The patient were examined visual acuity, anterior segment, IOP, metamorphopsia degree, and OCT for three consecutive times (before therapy, one day after therapy and fourteen days after therapy). Mann-Whitney test, Fisher’s Exact test and Wilcoxon test were used for statistical analysis. Result : twenty five eyes from fifteen patients were enrolled the study. Statistical analysis of this study showed that in treatment group treatment group on M-charts before therapy and after therapy (p = 0.003), and there was a significant change of INL thickness before therapy and after therapy (p = 0.001). In the control group there was no significant difference in the degree of vertical and horizontal metamorphopsia on M-charts before therapy and after therapy (p = 0.317), no significant difference in the degree of vertical and horizontal metamorphopsia was observed on the M-chart one day after therapy and 14 days of therapy (p = 0.317). In the treatment group, changes in INL and ONL thickness were found to be significantly different in one day before therapy and after therapy (p = 0.001), but no significant difference was found on examination one day after therapy and 14 days after therapy (p = 0.786). In the control group there was no significant difference in measurement of INL and ONL thickness before therapy and after therapy (p = 1,000). Conclusion : Hyperbaric oxygen therapy as adjuvant therapy, patient may accelerate the improvement metamorphopsia degree, INL and ONL thickness changes in AMD dry type

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