Setyawan, Dwi and Isadiartuti, Dewi and Betari, Sita Desti and Paramita, Diajeng Putri (2016) PHYSICAL CHARACTERIZATION OF IBUPROFEN-STEARIC ACID BINARY MIXTURE DUE TO COMPRESSION FORCE. Indonesian Journal of Pharmacy, 27 (1). pp. 28-34. ISSN 2338-9427

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Abstract

Aim of this research is to determine physical characteristic of ibuprofen-stearic acid due to compression force. Binary mixture of ibuprofen-stearic acid w ith weight ratio of 4:6, 5:5, and 6:4 was compressed under various compression force using hydraulic press w ith 13mm diameter flat punch. Identification of solid state interaction between these two components was performed by Hot Stage Microscopy (HSM). Physical characterization was studied using Differential Thermal Analysis (DTA), X-ray Powder Diffraction (XRPD), Scanning Electron Microscopy (SEM), and Fourier Transform Infrared (FT-IR) spectroscopy. According to hardness measurement, 4:6 weight ratio has the highest tensile strength on 170.6N/cm 2 under 19.93kN compression force. Interaction identification by HSM showed single blank line that indicates eutectic formation. Thermal analys is of DTA also revealed eutectic formation upon compression which the endothermic peak of ratio of 4:6 has the lowest melting temperature of 53.2°C. X-ray diffraction of three peaks generally showed that peak intensity decreases as compression force increases, but at particular point it begins to increase again. Sintering phenomenon at the surface of compressed tablet was observed from SEM analysis. FT-IR study confirms the formation of simple eutectic. Key words: ibuprofen, stearic acid, binary mixture, compression force, physical characterization

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