WINANTARI, AGNES NUNIEK and SETYAWAN, DWI and SISWODIHARDJO, SISWANDONO and SOEWANDHI, SUNDONO NURONO (2017) COCRYSTALLIZATION ACYCLOVIR-SUCCINIC ACID USING SOLVENT EVAPORATION METHODS. Asian Journal of Pharmaceutical and Clinical Research, 10 (6). pp. 91-94. ISSN 0974-2441

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Abstract

Objective: The aim of this research is to prepare and characterize cocrystals of acyclovir through cocrystallization of acyclovir-succinic acid (AS) to improve the physical properties of the drug. Methods: AS cocrystals were prepared using solvent evaporation method. The cocrystals were characterized by polarization microscope, scanning electron microscopy (SEM), differential scanning calorimetry, powder X-ray diffraction (PXRD), and Fourier transform infrared spectroscopy. Results: Physical characterization using polarization microscope and SEM showed the AS cocrystals have unique crystal habit and morphology. Phase diagram at a molar ratio of 50:50% (acyclovir:succinic acid) showed a decrease in the melting temperature, i.e., 176.23°C in comparison with the melting point of the constituent materials (acyclovir 253.53°C and succinic acid 187.29°C). The PXRD pattern of AS cocrystals (ethanol) exhibited new diffraction peaks at 2θ=5.91°; 9.16°; and 13.40°. Besides, cocrystals of AS (glacial acetic acid) indicated new peaks at 2θ=5.98°; 9.19°; and 13.43°. Furthermore, there was a shift in the N-H, O-H, and C=O. Conclusion: Cocrystallization of AS acid in ethanol and glacial acetic acid were successfully formed using solvent evaporation methods.

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